Synthesis and Antimicrobial Activity of Some New Piperazine Derivaties Containing Aryl Sulfonyloxy Group

Abstract

Novel N‐substituted piperazine derivatives containing sulfonyloxy aniline moiety have been prepared. The various 4‐sulfonyloxy aniline (SA) derivatives (2a‐h) have been prepared by the condensation reaction of N‐Acetyl Sulfanilyl chloride (ASC) and sodium phenates followed by hydrolysis. The SA derivatives are then reacted with chloro acetyl chloride to give corresponding (N‐Chloroacetyl) derivatives (3a‐h). These derivatives are then reacted with N‐phenyl piperazine to yield the corresponding piperazine derivatives (4a‐h).