Enzymuria in a population living near a cadmium battery plant

Abstract

Objectives - To study the body burden of cadmium and signs of tubular dysfunction in a rural population living near a closed nickel cadmium battery plant. Methods - Cadmium and N-acetyl-β- glucosaminidase (NAG) in urine were measured in 72 subjects who lived close to the plant. Results - Residents living close to the plant had higher median urinary cadmium concentrations than those living farther away (1.01 v 0.46 nmol/mmol creatinine) and than a control group (0.2 nmol/mmol creatinine). There was a significant correlation between urinary cadmium and the excretion of NAG in urine as we]l as signs of tubular dysfunction in residents who excreted urinary cadmium above 0.5 nmol/mmol creatinine. Conclusion - Tubular dysfunction may appear in environmentally exposed subjects at lower cadmium body burdens than previously anticipated.