The patient-at-risk for development of vulvar cancer

Abstract

Although the epithelial changes preceding the development of vulvar cancer were seemingly well defined in the early 20th century, recent changes in terminology have altered the interpretation of premalignant alterations as indefinite. The opportunity to follow the events leading to the development of invasive cancer suggest that chronic pruritis-associated atypical keratotic alterations may be the most significant premalignant features. © 1980.