Studies on a new Nucleoside Antibiotic, Dapiramicin II. Isolation, Physico-Chemical and Biological Characterization

Abstract

New nucleoside antibiotics, dapiramicins A and B produced by a Micromonospora sp. SF-1917, have been isolated by column chromatography on Diaion HP-20 and silica gel. Physico-chemical properties suggested that they are disaccharide nucleosides. Dapiramicin A underwent epimerization, under acidic condition, into epidapiramicin A. Although dapiramicin A generally exhibits no in vitro activity, it is very effective against the sheath blight of rice plants caused by Rhizoctonia solani in a green house test. © 1984, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.