SY36-1 * NUTRIENTS, NUTRITION, NUTRIGENOMICS AND NUTRIGENETICS IN ADDICTION DISORDERS

Abstract

Drug use is associated with inflammation, mitochondrial toxicity, oxidative stress, and regulation of pro-inflammatory cytokines, that may be further compounded by infections (HIV, HCV) leading to intestinal and systemic inflammations. Genetic factors play an important role in drug addiction. In gene-nutrients interactions, nutrients and genomics interact at two levels-nutrients can induce gene expression thereby altering individual phenotype. Conversely, single nucleotide polymorphisms, in a range of genes important in inflammation and lipid metabolism for example, alter the bioactivity of important metabolic pathways and mediators and influence the ability of nutrients to interact with them.