Correlation of Homocysteine Levels with Folate Acid, Cyanocobalamine, and Pyridoxine Serum Levels in Acute Infark Miocard Patients

Abstract

Cardiovascular disease is the cause of the highest mortality rate in the world. Acute myocardial infarction is one of the 5 major manifestations of coronary heart disease and the highest mortality rate in Indonesia. Hyperhomocysteinemia is one of the risk factors for the occurrence of acute myocardial infarction. The metabolism of homocysteine is influenced by folate acid, cyanocobalamin, and pyridoxine. Enzimsistationin-β-synthetase and cystationin-γ-liase that catalyze the transsulfuration of homocysteine are highly depended on pyridoxine. This study aims to determine the association of homocysteine with folate acid, cyanocobalamin, and pyridoxine serum levels in acute myocardial infraction patients. Cross-sectional design study with 25 samples of acute myocardial infraction patients are selected randomly. The research was conducted from July to December 2016 in Biomedical laboratory Andalas University. Homocysteine, folate acid, cyanocobalamin, and pyridoxine levels were examined by the ELISA method. Data is analyzed by the Pearson correlation test. The mean result of examination of homocysteine level was 23.17±9.2 nmol/mL, pyridoxine level 128.44 ± 34.02 pmol/L, cyanocobalamine level 188.79 ± 10.23 pmol/L and folate acid level 2.72 ± pmol/L. Statistic analysis test found that there is a significant relationship of levels of homocysteine with pyridoxine (r =-0.530), but there is a very weak relationship with cyanocobalamine and folate acid (r =-0.027 and-0.003). There is a significant relationship of homocysteine levels with pyridoxine serum on acute myocardial infarction patients. And there is a very weak relationship of homocysteine levels with cyanocobalamine and folate acid.