Palladium-catalyzed regioselective cross-dehydrogenative coupling of benzofurans with uracils at room temperature

Abstract

The Pd-catalyzed cross-dehydrogenative coupling (CDC) between two heteroarenes was developed. A variety of benzofuran and uracil derivatives were constructed through C-C bond formation by using CDC reactions. The substrates did not require prefunctionalization, and the products were obtained in good yields with good regioselectivities at room temperature. The Pd-catalyzed cross-dehydrogenative coupling (CDC) between two heteroarenes is developed. A variety of benzofuran and uracil derivatives are constructed in good yields with good regioselectivity at room temperature through C-C bond formation by using CDC reactions; prefunctionalization of the substrates is not required. PivOH = pivalic acid.