Pathway Miner: Extracting gene association networks from molecular pathways for predicting the biological significance of gene expression microarray data

Abstract

Summary: We have developed a web-based system (Pathway Miner) for visualizing gene expression profiles in the context of biological pathways. Pathway Miner catalogs genes based on their role in metabolic, cellular and regulatory pathways. A Fisher exact test is provided as an option to rank pathways. The genes are mapped onto pathways and gene product association networks are extracted for genes that co-occur in pathways. The networks can be filtered for analysis based on user-selected options. © Oxford University Press 2004; all rights reserved.