Adaptive designs from a Data Safety Monitoring Board perspective: Some controversies and some case studies

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Abstract

This article describes vignettes concerning interactions with Data Safety Monitoring Boards during the design and monitoring of some clinical trials with an adaptive design. Most reflect personal experiences by the author.

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Turnbull, B. W. (2017). Adaptive designs from a Data Safety Monitoring Board perspective: Some controversies and some case studies. In Clinical Trials (Vol. 14, pp. 462–469). SAGE Publications Ltd. https://doi.org/10.1177/1740774516689261

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