Protective effect of vitamin e against moxifloxacin induced side effect in rats

Abstract

Our investigation was carried out to assess the protective effect of vitamin E against the moxifloxacin-induced side effects in rats. A total of 80 adult male albino rats were allocated into four equal groups. The first group represented as a control and given physiological saline. The second and third groups were orally received vitamin E (18 mg/kg BW) and moxifloxacin (7.2 mg/kg BW), respectively for 21 successive days. The fourth group was received Vit E concurrently with moxifloxacin for 21 successive days. Administration of moxifloxacin to albino rats resulting in a significant increase in the activities of ALT (Alanine aminotransferase), AST (aspartate aminotransferase), ALP (alkaline phosphatase) beside significant decrease in the levels of total serum protein and albumin, in addition to an elevation in serum creatinine and urea all over the experimental period compared with control group. In addition, a significant decrease in catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) as well as a significant elevation of malondialdehyde (MDA) concentration were recorded in moxifloxacin-treated group when compared with the control group. The histopathological alterations in liver and kidney of the examined rats confirmed the obtained biochemical results. Co-administration of moxifloxacin with Vit E for 21 successive day resulting in a significant reduction of the activities of liver enzymes, creatinine and urea, while serum total proteins, albumin and globulins turned toward the normal levels beside an elevation of CAT, SOD and GPx with a significant decrease in the concentration of MDA when compared with moxifloxacin alone-treated group. Our results revealed that Vit E could protect against moxifloxacin-induced side effects. Therefore, Vitamin E should be taken with moxifloxacin to decrease its adverse effects.