Synthesis of a racemic nicotine-lobeline hybrid

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Abstract

The first synthesis of a racemic nicotine-lobeline hybrid is described based on a diastereoselective allylation and an RCM reaction as key steps. This synthetic route paves the way to the preparation of original potential ligands of nAChRs. © Georg Thieme Verlag Stuttgart New York.

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Ranaivondrambola, T., Hatton, W., Felpin, F. X., Evain, M., Mathé-Allainmat, M., & Lebreton, J. (2010). Synthesis of a racemic nicotine-lobeline hybrid. Synlett, (11), 1631–1634. https://doi.org/10.1055/s-0029-1219966

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