Synthesis and Muscle Relaxant Properties of 3-amino-4-arylpyrazoles

Abstract

A new synthesis of 3-amino-4-arylpyrazoles involving the acetic acid catalyzed reaction of hydrazine with α-formylarylacetonitriles is described. Seventeen new pyrazoles in this series are reported, as well as thirteen new N-substituted derivatives of 3-amino-4-phenylpyrazole. While a number of these compounds exhibited muscle relaxant activity, 3-amino-4-phenylpyrazole was the most active. Structure-activity relationships are discussed. © 1964, American Chemical Society. All rights reserved.