Conversion of a DCHA salt to the free acid

Abstract

Bachem offers a number of N-protected amino acids as DCHA (dicyclohexylammonium) salts. The production of such salts is preferred if the free amino acid is not available in a crystalline form or if the free acid is unstable. In addition, in some cases DCHA salts of derivatives can be purified in a straight-forward process. An example represents the separation of racemates using their diastereomeric salts. However, before starting peptide synthesis, the amino acids have first to be liberated from their DCHA salts.