Potential use of silver nanoparticles on pathogenic bacteria, their toxicity and possible mechanisms of action

Abstract

The antimicrobial properties of silver have been known for thousands of years. Recently, silver nanoparticles have gained attention because of their antimicrobial activity which offers the possibility of their use for medical and hygiene purposes. Indeed, silver nanoparticles in different formulations and with different shapes and sizes exhibit variable antimicrobial activity. However, the mechanisms of antimicrobial activity of silver ions and silver nanoparticles, and their toxicity to human tissues are not fully characterized. This review evaluates the potential use of silver nanoparticles to control pathogens with emphasis on their action against pathogenic bacteria, their toxicity and possible mechanisms of action. © 2010 Sociedade Brasileira de Química.