STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production

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Abstract

Li et al. show that STING mediates negative feedback regulation of IFI16 and restricts type I IFN overproduction during immune responses to viruses such as HSV-1.

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Li, D., Wu, R., Guo, W., Xie, L., Qiao, Z., Chen, S., … Ma, F. (2019). STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production. Cell Reports, 29(5), 1249-1260.e4. https://doi.org/10.1016/j.celrep.2019.09.069

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