Researches on Chemotherapeutic Drugs against Viruses. XXXIV. Syntheses and Antiviral Activity of 10-(

Abstract

Fifteen compounds of 10-(-dialkylaminoalkyl)-alkylphenothiazine series, nine compounds of 10-(2-pyridiniumacetyl)-alkylphenothiazine series, three compounds of 10-[2-(1-piperidyl)-acetyl]-alkylphenothiazine series, and three compounds of 10-(2-trimethyl-ammoniumacetyl)alkylphenothiazine iodide series, which were substituted with alkyl group in 1-, 2-, or 3-position of the phenothiazine ring, were synthesized and their antiviral activity on adenovirus was tested by the tissue culture method. Among these compounds, 10-(3-diethylaminopropyl)-3-methyl- and 10-(3-diethylaminopropyl)-3-ethylphenothiazine' and all compounds of 10-(2-pyridiniumacetyl)-alkylphenothiazine chloride series were found to possess direct inactivating effect on the adenovirus. On cytopathogenic effect induced by adenovirus, 10-(3-diethylaminopropyl)-3-methyl and 10-(3-diethylaminopropyl)~ 3-ethyl derivatives also inhibited in 5TCD50 of virus. © 1962, The Pharmaceutical Society of Japan. All rights reserved.