Regulation of rat neuronal nitric oxide synthase activity by chronic alcoholization

Abstract

Rat neuronal nitric oxide (NO) synthase (nNOS) activity was measured in frontal cortex, hippocampus, striatum and cerebellum using the assay of [3H]citrulline, following chronic alcoholization. The K(m) and V(max), values were significantly increased in the frontal cortex and in the striatum, and were not affected in the cerebellum and hippocampus.