Diurnal variation in insulin sensitivity of glucose metabolism is associated with diurnal variations in whole-body and cellular fatty acid metabolism in metabolically normal women

Abstract

Context: The mechanism(s) responsible for diurnal variations in insulin sensitivity of glucose metabolism in healthy people are unclear. Copyright Objective: The objective of the study was to evaluate whether diurnal variations in whole-body and cellular fatty acid metabolism could contribute to evening insulin resistance in metabolically normal people. Subjects and Design: We measured plasma the free fatty acid (FFA) concentration, palmitate kinetics, and skeletal muscle expression of genes involved in fatty acid metabolism at breakfast (7:00AM)anddinner (7:00 PM) in13 overweight (body mass index 27.8±1.2 kg/m2) but metabolically normal, women. Results: Plasma FFA concentration was approximately 30% greater just before consuming dinner than breakfast (P