Genetic factors in pathogenesis of chronic periodontitis

Abstract

Chronic periodontitis is a global health problem that affects the majority of adult population worldwide. The inflammatory destruction of tooth supporting structure is multifactorial in nature. It results from interaction between microbial, environmental, immunologic, and genetic factors. The exact mechanism of action by which genetic factors alter the course of chronic periodontitis and aid in pathogenesis is yet not well understood. Studies suggest association genetic polymorphism and susceptibility to chronic periodontitis. It is recommended that further investigation of a larger sample size with consideration of interaction with other factors that contribute to the pathogenesis of chronic periodontitis.