Home environment as a source of life-threatening azole-resistant aspergillus fumigatus in immunocompromised patients

Abstract

A case of fatal aspergillosis due to a TR46/Y121F/T289A azoleresistant Aspergillus fumigatus is reported. Environmental investigations at the patient's residence led to the recovery of TR46/Y121F/T289A isolates, genotypically indistinguishable from the clinical isolate, supporting for the first time the direct role of household as potential source of azole-resistant invasive aspergillosis.