Molecular investigations of the development and diseases of cerebral cortex folding using gyrencephalic mammal ferrets

Abstract

Folds of the cerebral cortex (gyri and sulci) are among the most important properties of the mammalian brain. Uncovering the physiological roles, developmental mechanisms and evolution of the cortical folds would greatly facilitate our understanding of the human brain and its diseases. Although the anatomical features of the cortical folds have been intensively investigated, our knowledge about their molecular bases is still limited. To overcome this limitation, we recently established rapid and efficient genetic manipulation techniques for the brain of gyrencephalic mammal ferrets (Mustela putorius furo). Using these techniques, we successfully uncovered the molecular mechanisms of cortical folding. In this article, I will summarize our recent research on the molecular mechanisms of development and diseases of cortical folding.