Neurotoxicity of acrylamide and its analogues and effects of these analogues and other agents on acrylamide neuropathy

Abstract

N Hydroxymethylacrylamide, N methylacrylamide and N,N diethylacrylamide produce peripheral neuropathy in rats. Seven other compounds related to acrylamide do not produce neuropathy. Rats given one of the three neurotoxic compounds are more susceptible to acrylamide. A regime for testing acrylamide analogues for neurotoxicity is suggested. DDT, phenobarbitone or high dietary concentrations of vitamin A or E have no effect on the development of acrylamide neuropathy in rats. Acrylamide produces neuropathy in hens but not in frogs or goldfish.