Treatment of Mycoplasma genitalium. Observations from a Swedish STD Clinic

108Citations
Citations of this article
75Readers
Mendeley users who have this article in their library.

Abstract

Objectives: To evaluate therapy for Mycoplasma genitalium infection with doxycycline or azithromycin 1 g compared to five days of azithromycin (total dose 1.5 g). Methods: A retrospective case study was performed among patients attending the STD-clinic in Falun, Sweden 1998-2005. All patients with a positive PCR test for M. genitalium were routinely offered a test of cure (toc). Response to doxycycline for 9 days, azithromycin 1 g single dose and extended azithromycin (500 mg on day 1 followed by 250 mg o.d. for 4 days) was determined. In patients with treatment failure after azithromycin, macrolide resistance was monitored before and after treatment. Furthermore, the rate of macrolide resistance was monitored for positive specimens available from 2006-2011. Results: The eradication rate after doxycycline was 43% (48% for women and 38% for men), for azithromycin 1 g 91% (96% for women and 88% for men) and for extended azithromycin 99% (100% for women and 93% for men). Macrolide resistance developed in 7/7 examined (100%) of those testing positive after azithromycin 1 g, but in none of those treated with extended azithromycin. Macrolide resistance before treatment increased from 0% in 2006 and 2007 to 18% in 2011. Conclusions: These findings confirm the results from other studies showing that doxycycline is inefficient in eradicating M. genitalium. Although azithromycin 1 g was not significantly less efficient than extended dosage, it was associated with selection of macrolide resistant M. genitalium strains and should not be used as first line therapy for M. genitalium. Monitoring of M. genitalium macrolide resistance should be encouraged. © 2013 Anagrius et al.

References Powered by Scopus

Mycoplasma genitalium: From chrysalis to multicolored butterfly

414Citations
N/AReaders
Get full text

A NEWLY DISCOVERED MYCOPLASMA IN THE HUMAN UROGENITAL TRACT

394Citations
N/AReaders
Get full text

Azithromycin treatment failure in Mycoplasma genitalium-positive patients with nongonococcal urethritis is associated with induced macrolide resistance

287Citations
N/AReaders
Get full text

Cited by Powered by Scopus

2016 European guideline on Mycoplasma genitalium infections

262Citations
N/AReaders
Get full text

2015 European guideline on the management of Chlamydia trachomatis infections

212Citations
N/AReaders
Get full text

Prevalence of mutations associated with resistance to macrolides and fluoroquinolones in Mycoplasma genitalium: a systematic review and meta-analysis

188Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Anagrius, C., Loré, B., & Jensen, J. S. (2013). Treatment of Mycoplasma genitalium. Observations from a Swedish STD Clinic. PLoS ONE, 8(4). https://doi.org/10.1371/journal.pone.0061481

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 24

73%

Researcher 5

15%

Professor / Associate Prof. 4

12%

Readers' Discipline

Tooltip

Medicine and Dentistry 13

36%

Agricultural and Biological Sciences 12

33%

Immunology and Microbiology 7

19%

Biochemistry, Genetics and Molecular Bi... 4

11%

Article Metrics

Tooltip
Mentions
References: 3
Social Media
Shares, Likes & Comments: 19

Save time finding and organizing research with Mendeley

Sign up for free