We assessed the effects of lodenafil on hemodynamics and inflammation in the rat model of monocrotaline-induced pulmonary hypertension (PH). Thirty male Sprague-Dawley rats were randomly divided into three groups: control; monocrotaline (experimental model); and lodenafil (experimental model followed by lodenafil treatment, p.o., 5 mg/kg daily for 28 days) Mean pulmonary artery pressure (mPAP) was obtained by right heart catheterization. We investigated right ventricular hypertrophy (RVH) and IL-1 levels in lung fragments. The number of cases of RVH was significantly higher in the monocrotaline group than in the lodenafil and control groups, as were mPAP and IL-1 levels. We conclude that lodenafil can prevent monocrotaline-induced PH, RVH, and inflammation.
CITATION STYLE
Polonio, I. B., Acencio, M. P. M., Pazetti, R., de Almeida, F. M., da Silva, B. S., Pereira, A. B. K., & Souza, R. (2014). Lodenafil treatment in the monocrotaline model of pulmonary hypertension in rats. Jornal Brasileiro de Pneumologia, 40(4), 421–424. https://doi.org/10.1590/S1806-37132014000400010
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