Antlion (Myrmeleon sp.) Infusion as Antidiabetic in Dexamethasone Induced Mice

Abstract

Diabetes Mellitus (DM) is a degenerative disease which classified as number 6 death caused worldwide mark by hyperglycemia condition. Antlion (Myrmeleon sp.) used as antidiabetic traditionally in Tasikmalaya. This research aims to evaluate antlion (Myrmeleon sp.) infusion antidiabetic activity. Dexamethasone was used to induce hyperglycemia condition in all treatment group. Negative group were given CMC 0,5%, positive group were given metformin 1,3 mg/20 g bw, dose 1, dose 2 and dose 3 were given antlion infusion 0,104 mg/20 g bw, 0,208 mg/20 g bw and 0,416 mg/20 g bw respectively. The effect of antlion infusion was observed at 0, 30, 60, 90 and 120 minutes. Antlion infusion has an antidiabetic activity which dose 2 showed the best effect in decreasing blood glucose. The best blood glucose decreasement (BGC) come out from dose 2 with % BGC at 60, 90 and 120 minutes 28,19%, 28,39 %, and 31,20 % respectively.