Obesity accelerates aging: Mechanisms and therapeutic implications

Abstract

Global aging is increasing, and both aging and age-related diseases have emerged as significant public health challenges. According to previous literature, aging is characterized by multiple hallmarks, such as systemic inflammation, telomere depletion, mitochondrial dysfunction, and others. Obesity is a chronic and complex disease. Notably, obesity can accelerate the aging process and shares several similar features with aging. Therefore, this review systematically summarizes the relationship between obesity and aging, and discusses the great potential of anti-obesity therapies in combating aging and aging-related diseases.