Genetic and biochemical studies on the regulatory mechanism of the self-resistance and biosynthesis of antibiotics

Abstract

The following topics are described: 1. chemistry of β-lactamases; 2. β-lactamases from Streptomyces including distribution of β-lactamases in actinobacteria, properties of β-lactamases from Streptomyces, cloning and regulatory mechanism of expression of β-lactamase genes from Streptomyces and evolution and classification of β-lactamases in general; 3. penicillin-binding proteins from Streptomyces including β-lactam-producing- and non-producing strains and 4. eukaryotic-type protein kinases from Streptomyces including cloning of the genes and evolution and classification of eukaryotic-type protein kinases in general.