The contribution of HPV18 to cervical cancer is underestimated using high-grade CIN as a measure of screening efficiency

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Abstract

In one geographical area, 14 high-risk human papillomavirus types in cervical intraepithelial neoplasia (CIN2/3; n=139) and cervical squamous cell carcinoma (SCC; n=84) were analysed. HPV18 was more prevalent in SCC than CIN2/3 (OR 9.8; 95% confidence interval: 2.5-39). Other high-risk types prevalences corresponded in CIN2/3 and SCC. Evaluations using CIN2/3 as a measure of efficiency underestimate the contribution of HPV18 to SCC. © 2007 Cancer Research UK.

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Bulk, S., Berkhof, J., Rozendaal, L., Daalmeijer, N. C. F., Gök, M., De Schipper, F. A., … Meijer, C. J. L. M. (2007). The contribution of HPV18 to cervical cancer is underestimated using high-grade CIN as a measure of screening efficiency. British Journal of Cancer, 96(8), 1234–1236. https://doi.org/10.1038/sj.bjc.6603693

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