Assessment of flavonoids as rutin for detoxification of T-2 toxin

Abstract

To assess the efficacy of rutin, a flavonoid, for detoxifying T-2 toxin, 30 male albino rats were divided in 3 equal groups. Group 1 served as control. Rats in groups 2 and 3 were given 0.1 mg I kg bw T-2 toxin and those of group 3 were given 50 mg I kg rutin additionally. Toxin in liver tissue increased TBARs, SOD, GST, total lipids and decreased total thiol and catalase. Similarly there was increased lipid peroxide and decrease in total thiol, GST, hemoglobin and hematocrit value. All these were improved in group 3. The result suggest that rutin may be used as anti oxidant for T-2 toxin in liver of rat. © GSP, India.