Central nervous system active compounds. II*. The synthesis of some 4-, 5-, 6-and 7-substituted caprolactams

Abstract

The synthesis of caprolactam derivatives substituted at C4, C5, C6 and C7 with alkyl, aryl, acyl and hetero substituents is described. A variety of synthetic approaches to these compounds have been investigated and assessed, particularly for the synthesis of C4-and C6-substituted compounds. A significant number of the C4-, C6-and C7-substituted compounds prepared show central nervous system activity, ranging from convulsants to depressants depending on the position and nature of the substituent group. © 1976 CSIRO.