Possible role of hydrogen sulfide in insulin secretion and in development of insulin resistance

Abstract

H2 S has been proposed as physiological important molecule. It is considered as first endogenous gaseous K+ channel opener. K + ATP channel activity is mainly responsible for insulin secretion. K+ATP channel opening of cells leads to inhibition of insulin secretion and channels closing leads to secretion. H2S is the gaseous K + ATP channel opener but it does not have channel specificity. So, H2 S may have some effect on insulin secretion. H2 S is high in Zuker diabetic fatty rats. That means H2 S is high in insulin resistance condition. We tried to find out the role of H2 S in insulin secretion and in development of insulin resistance. From the result of our study, H2 S have K+ ATP channel opening activity on cells. H2 S does not have any role in the development of insulin resistance. Decrease in insulin level in Zuker diabetic rat and streptozotocin-induced diabetic rat is due to high H2 S level.