Efficient Conversion of Nitriles to Amides with Basic Hydrogen Peroxide in Dimethyl Sulfoxide

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Abstract

Nitriles 1 are efficiently transformed into N-unsubstituted amides 2 at 20°C in 5-30 mins in good yield and with high selectivity, using basic 30% hydrogen peroxide in dimethyl sulfoxide.

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Katritzky, A. R., Pilarski, B., & Urogdi, L. (1989). Efficient Conversion of Nitriles to Amides with Basic Hydrogen Peroxide in Dimethyl Sulfoxide. Synthesis (Germany), 1989(12), 949–950. https://doi.org/10.1055/s-1989-27441

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