EFFECTIVENESS OF HIGH AND LOW INTENSITY REHABILITATION PROGRAMME IN CHRONIC PHASE OF GUILLAIN BARRE SYNDROME PATIENTS: A RANDOMIZED CONTROL TRIAL

Abstract

Aim of the study: The aim of the study was to conduct a randomized control trial to compare the effectiveness of high and low intensity rehabilitation programme in chronic phase of GBS patient. Methodology: 20 Patients were included in the study as per inclusion and exclusion criteria. A written informed consent was signed by the subjects in their native language. The subjects were divided into two groups by simple random sampling. Group (A) Experimental Group (N=10): got treatment with High intensity rehabilitation exercises and Group (B) Control Group (N=10): got treatment with Low intensity rehabilitation exercises. Total rehabilitation program was for 12 months. The outcome measures for the both groups were Functional Independence Measure (FIM), World health Organization Quality of Life Scale (WHOQOL-BREF), Perceived Impact of Problem Profile (PIPP). Results: Intention to treat analysis of data from 20 patients (experimental n=10, control n=10) showed reduced disability in the treatment group in post-treatment FIM domains (self- care, sphincter control, transfers, locomotion; all p<0.001) and WHOQOL-BREF domains (quality of life; all p<0.001) and PIPP domains (self-care, mobility; all p<0.001). The treatment group compared with control group showed significant improvement in function (FIM scores): 72% vs. 50%. Conclusion: High intensity rehabilitation programme compared with Low intensity low intensity rehabilitation programme is effective in reducing motor disability (mobility, self-care, continence) in chronic phase of GBS patients. Article visualizations: