Modulation of aggregation behaviour of amphiphlic drug and surfactant mixture under the influence of neutral polymer

Abstract

The interaction of ram-ionic surfactant, Trion X-114 (TX-114) with amphiphilic drug i.e., imipramine hydrochloride (IMP) has been i investigated by surface tension measurement in the absence and presence of hydroxyprupy1 methylcellulose (HPMC) polymer. In the presence of the HPMC the plots of surface tension versus concenttration of TX-114 + IMP mixed system show Interesting features (i.e.. two break points). The two break points attributed to the occurrence of two kind of aggregation process, In the presence of HPMC, the first break is close lo that in pure water, can be regarded as critical aggregation concentration (cac), whereas second one is 2-3 times higher than Ihe first one and can be attributed to (the polymer bound micelles. The interfacial and bulk behavior was investigaled using various theoretical models of Clint. Rosen, Rubingh etc. Synergism was observed in all binary combinations in the micelle and at the inlerince with or without the HPMC. Various thermodynamic parameter have been calculated with ihe help of regular solution theory (RST) and pseudo phase model for micellization.