SynthesisPyrazine andandPhenazineDrug DiscoveryHeterocycles: Platforms for Total Synthesis and Drug Discovery

Abstract

There are numerous pyrazine and phenazine compounds that demonstrate biological activities relevant to the treatment of disease. In this review, we discuss pyrazine and phenazine Abstract: There are numerous pyrazine and phenazine compounds that demonstrate biological activities relevant to the treatment of disease. In this review, we discuss pyrazine and phenazine agents that have shown potential therapeutic value, including several clinically used agents. In addition, we cover some basic science related to pyrazine and phenazine heterocycles, which possess agents that have shown potential therapeutic value, including several clinically used agents. In addition, we cover some basic science related to pyrazine and phenazine heterocycles, which possess interesting reactivity profiles that have been on display in numerous cases of innovative total synthesis approaches, synthetic methodologies, drug discovery efforts, and medicinal chemistry pro-interesting reactivity profiles that have been on display in numerous cases of innovative total synthesis approaches, synthetic methodologies, drug discovery efforts, and medicinal chemistry programs. The grams. The majority of this review is focused on presenting instructive total synthesis and medicinal majority of this review is focused on presenting instructive total synthesis and medicinal chemistry chemistry efforts of select pyrazine and phenazine compounds, and we believe these incredible heterocycles offer promise in medicine. efforts of select pyrazine and phenazine compounds, and we believe these incredible heterocycles offer promise in medicine.