Use of l,3-Dioxin-4-ones and Related Compounds in Synthesis. Asymmetric Aldol Reaction of 4-Trimethylsiloxy-6-methylene-l,3-dioxines Use of Tartaric Acid-Derived (Acyloxy) borane Complex as the Catalyst

Abstract

A novel enantioselective synthesis of l,3-dioxin-4-ones having a 2-hydroxylated alkyl group at the 6-position has been accomplished by chiral tartaric acid-derived acylborane-mediated aldol condensation of the silyl enol ether derived from 6-methyl-derivatives of 1,3-dioxin-4-one with achiral aldehydes. © 1994, The Pharmaceutical Society of Japan. All rights reserved.