Transcription factors SOX4 and SOX11 function redundantly to regulate the development of mouse retinal ganglion cells

Abstract

Background: Roles of SoxC genes in the development of retinal ganglion cells (RGCs) are unknown at present. Results: Targeted deletion of Sox4 and Sox11 in retina results in a complete loss of RGCs. Conclusion: Sox4 and Sox11 function redundantly to regulate RGC development. Significance: These findings highlight the essential role of SoxC genes in retinal development. © 2013 by The American Society.