Journal ArticleOPEN ACCESS

Targeting Effect Compartment or Central Compartment Concentration of Propofol

  • Wakeling H
  • Zimmerman J
  • Howell S
  • et al.
Anesthesiology (1999) 90(1) 92-97
DOI: 10.1097/00000542-199901000-00014
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Abstract

An effect compartment has been postulated, and the ke0 has been quantified for several intravenous anesthetic drugs using electroencephalography (EEG) as the measure of effect. The authors wanted to validate that loss of responsiveness (LOR) was related to targeting an effect compartment concentration rather than a central compartment (plasma) concentration.

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Wakeling, H. G., Zimmerman, J. B., Howell, S., & Glass, P. S. A. (1999). Targeting Effect Compartment or Central Compartment Concentration of Propofol. Anesthesiology, 90(1), 92–97. https://doi.org/10.1097/00000542-199901000-00014

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