Impact of Vegan Diets on Resistance Exercise-Mediated Myofibrillar Protein Synthesis in Healthy Young Males and Females: A Randomized Controlled Trial

Abstract

Background Protein ingestion stimulates muscle protein synthesis (MPS) rates to support the turnover of skeletal muscle protein mass. However, dietary patterns consist of a variety of protein foods with different amino acid compositions consumed at multiple meal times throughout the day. Omnivorous (OMN) and vegan (VGN) dietary patterns may differentially stimulate MPS. Moreover, the distribution and frequency of protein intake may also play an important anabolic regulatory role. Objective We aimed to determine the effect of OMN and VGN dietary patterns and protein distribution (balanced (B) and unbalanced (UB)) in regulating changes in daily myofibrillar protein synthesis rates during a 9-d resistance training intervention. Design Forty healthy, physically active males and females (28 males, 12 females; 25 ± 4 yr; body mass index, 24.1 ± 2.1 kg·m-2) consumed a weight-maintenance diet providing 1.1-1.2 g·kg-1·d-1 of dietary protein from an OMN or VGN dietary pattern with UB (10%, 30%, and 60% of daily protein at meals 1, 2, and 3, respectively) or B (20% of daily protein at five eating occasions) distribution. Participants completed whole-body resistance exercise three times during the controlled feeding trial while consuming deuterated water (D2O) for the measurement of daily myofibrillar protein synthesis rates. Results The percent kilocalories from carbohydrate was higher (P = 0.045) in the OMN compared with VGN groups, but no other differences in dietary intakes were observed. Myofibrillar protein synthesis rates did not differ between the OMN-UB (3.04% ± 1.85%·d-1), OMN-B (2.43% ± 1.21%·d-1), VGN-UB (2.52% ± 1.77%·d-1), and VGN-B (2.49% ± 1.56%·d-1) groups (all P > 0.05). Conclusions Our results demonstrated that the anabolic action of animal versus vegan dietary patterns is similar. Moreover, there is no regulatory influence of distribution between the two dietary patterns on the stimulation of myofibrillar protein synthesis rates in young adults. This trial was registered with ClinicalTrials.gov (NCT04232254).