Concise synthesis of biologically interesting (±)-cannabichromene, (±)-cannabichromenic acid, and (±)-daurichromenic acid

Abstract

Total synthesis of biologically interesting (±)-cannabichromene, (±)-cannabichromenic acid, and (±)-daurichromenic acid is described. The key step in the synthetic strategy involves the formation of benzopyrans by ethylenediamine diacetate-catalyzed reactions of resorcinols with α,β-unsaturated aldehydes.