Abstract
The molecular weight of 3 preparations of human papilloma virus DNA derived from different plantar warts was determined by agarose gel electrophoresis or electron microscope contour length measurement. It was found to amount to approximately 4.9 x 106. Analysis of this DNA after sequential digestion by 4 different restriction endonucleases (EcoRI, Bam, Hind II, and Hind III) permitted physical mapping of the cleavage sites. 2 of the 3 DNA preparations revealed an identical cleavage pattern, whereas the third one contained 2 additional cleavage sites.
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CITATION STYLE
Gissmann, L., & Zur Hausen, H. (1976). Human papilloma virus DNA: physical mapping and genetic heterogeneity. Proceedings of the National Academy of Sciences of the United States of America, 73(4), 1310–1313. https://doi.org/10.1073/pnas.73.4.1310
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