Synthesis of novel pyrazolines and their antimicrobial activity

Abstract

A series of novel 4-nitroaniline derived pyrazolines have been synthesized and characterized by data arrived from the analytical methods such as FT-IR,1H NMR,13C NMR and Mass spectral analysis. X-ray crystallographic structure elucidation of a crystalline compound 4-fluoro benzaldehyde derived chalcone is presented. The impact of electronegativity and extension of conjugation offered by the nitro group in the synthesized molecule on its biological activity was analyzed. Title compounds were subjected to antimicrobial activity.