Evaluation of antimicrobial and synergistic effects of selected medicinal plants of Hail area with antibiotics

Abstract

In this study, the antibacterial activity of selected medicinal plants and their synergistic effect with antibiotics were investigated. Different antibiotic resistant bacterial species were employed including: Escherichia coli (E. coli), Klebsiella pneumoniae (K. pneumonia), Acinetobacter baumannii (A.baumannii), Pseudomonas aeruginosa (P. aeruginosa), Staphylococcus aureus (S. aureus) and Salmonella spp. The results indicated that methanol extracts of most of the tested plants inhibited growth of the tested bacteria, however, the highest inhibition was by Senna followed by Harmal, safflower and Guaada, where the inhibition zone diameter was 8 mm, 4 mm, 3 mm, 2 mm and 2 mm, respectively. The synergism between plants extract and antibiotics resulted in inhibition of the tested organisms; generally, the synergism with Harmal extract was more effective in inhibition of antibiotic-resistant bacteria, followed by Senna and finally Safflower. The outcomes additionally demonstrated that methanolic concentrate of the plant has more inhibitory impact than that of the water extract. Further investigation of the plants extract to seclude and recognize the dynamic fixings is prescribed.