Abstract
Fluorescence lifetime imaging ophthalmoscopy (FLIO) is an emerging technology, which enables the time-resolved in-vivo measurement of fluorescence emitted by endogenous fluorophores within the retina. The decay time of the fluorescence is a characteristic parameter for fluorescent molecules and their environment, and therefore FLIO is a promising tool to detect and assess varying metabolic states of different areas in the retina. The system is based on a confocal scanning laser ophthalmoscope with an implemented real-time eye tracking system. The fluorophores are excited by picosecond laser pulses and the fluorescence emission is detected using time correlated single photon counting (TCSPC) technology.
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CITATION STYLE
Bernstein, P., Dysli, C., Fischer, J., Hammer, M., Katayama, Y., Sauer, L., & Zinkernagel, M. S. (2019). Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO). In High Resolution Imaging in Microscopy and Ophthalmology (pp. 213–235). Springer International Publishing. https://doi.org/10.1007/978-3-030-16638-0_10
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