Total synthesis of (-)-epimyrtine by a gold-catalyzed hydroamination approach

Abstract

A new approach to the total synthesis of (-)-epimyrtine has been developed from D-alanine. The key step to access the enantiopure pyridone intermediate was achieved by a gold-mediated cyclization. Finally, various transformations afforded the natural product in a few steps and good overall yield. © 2013 Trinh et al; licensee Beilstein-Institut.