Activation of the nuclear factor E2-related factor 2 pathway by novel natural products halomadurones A-D and a synthetic analogue

25Citations
Citations of this article
24Readers
Mendeley users who have this article in their library.

Abstract

Two novel chlorinated pyrones, halomadurones A and B, and two novel brominated analogues, halomadurones C and D, were isolated from a marine Actinomadura sp. cultivated from the ascidian Ecteinascidia turbinata. Additionally, a non-halogenated analogue, 2-methyl-6-((E)-3-methyl-1,3- hexadiene)-γ-pyrone, was synthesized to understand the role of the halogens for activity. Halomadurones C and D demonstrated potent nuclear factor E2-related factor antioxidant response element (Nrf2-ARE) activation, which is an important therapeutic approach for treatment of neurodegenerative diseases. © 2013 by the authors; licensee MDPI.

Cite

CITATION STYLE

APA

Wyche, T. P., Standiford, M., Hou, Y., Braun, D., Johnson, D. A., Johnson, J. A., & Bugni, T. S. (2013). Activation of the nuclear factor E2-related factor 2 pathway by novel natural products halomadurones A-D and a synthetic analogue. Marine Drugs, 11(12), 5089–5099. https://doi.org/10.3390/md11125089

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free