Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster

Abstract

Aging is associated with NF-κB-dependent pro-inflammation. Here we demonstrated that inhibition of NF-κB with pyrrolidine dithiocarbamate increases the median lifespan (13-20%) and the age of 90% mortality (11-14%) in Drosophila melanogaster females and males, respectively. © Moskalev and Shaposhnikov.