Ultrasonic synthesis and biomedical application of mn0.5 zn0.5 erx yx fe2−2x o4 nanoparticles

Abstract

In the present study, biocompatible manganese nanoparticles have been linked with zinc and iron molecules to prepare different derivatives of Mn0.5 Zn0.5 Erx Yx Fe2−2x O4 NPs (x = 0.02, 0.04, 0.06, 0.08, 0.10), using an ultrasonication approach. The structure, surface morphology, and chemical compositions of Mn0.5 Zn0.5 Erx Yx Fe2−2x O4 NPs were elucidated by X-ray diffractome-ter (XRD), High-resolution transmission electron microscopy (HR-TEM), scanning electron mi-croscope (SEM), and Energy Dispersive X-Ray Analysis (EDX) techniques. The bioactivity of Mn0.5 Zn0.5 Erx Yx Fe2−2x O4 NPs on normal (HEK-293) and (HCT-116) colon cancer cell line was evaluated. The Mn0.5 Zn0.5 Erx Yx Fe2−2x O4 NPs treatment post 48 h resulted in a significant reduction in cells (via MTT assay, having an IC50 value between 0.88 µg/mL and 2.40 µg/mL). The specificity of Mn0.5 Zn0.5 Erx Yx Fe2−2x O4 NPs were studied by treating them on normal cells line (HEK-293). The results showed that Mn0.5 Zn0.5 Erx Yx Fe2−2x O4 NPs did not incur any effect on HEK-293, which suggests that Mn0.5 Zn0.5 Erx Yx Fe2−2x O4 NPs selectively targeted the colon cancerous cells. Using Candida albicans, antifungal activity was also studied by evaluating minimum inhibitory/fungicidal concentration (MIC/MFC) and the effect of nanomaterial on the germ tube formation, which exhibited that NPs significantly inhibited the growth and germ tube formation. The obtained results hold the potential to design nanoparticles that lead to efficient bioactivity.