Pharmaceutical hydrates under ambient conditions from high-pressure seeds: A case study of GABA monohydrate

Abstract

The monohydrate form of the neurotransmitter β-amino butyric acid (GABA) has been crystallised in the 0.4–0.8 GPa pressure range, recovered to ambient pressure and then used as a seed. Theoretical calculations indicate that this hydrate is only thermodynamically favoured over the two anhydrous forms at high pressures. 2014 © The Royal Society of Chemistry.