Continuous-flow hydration-condensation reaction: Synthesis of αβ-unsaturated ketones from alkynes and aldehydes by using a heterogeneous solid acid catalyst

Abstract

A simple, practical and efficient continuous-flow hydration-condensation protocol was developed for the synthesis of α,β-unsaturated ketones starting from alkynes and aldehydes by employing a heterogeneous catalyst in a flow microwave. The procedure presents a straightforward and convenient access to valuable differently substituted chalcones and can be applied on multigram scale. © 2011 Rueping et al; licensee Beilstein-Institut.